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| 1st(1st leg) | Deportivo Guadalajara | - | UANL Tigres | 3:1 (1:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | Deportivo Guadalajara | 1:1 (0:0) | ||
| 1st(1st leg): 05/05/2011 01:00 | 2nd (2nd leg): 08/05/2011 01:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Cruz Azul | - | Atlante | 2:1 (1:1) | ||
| 2nd (2nd leg) | Atlante | - | Cruz Azul | 0:0 (0:0) | ||
| 1st(1st leg): 05/05/2011 03:00 | 2nd (2nd leg): 08/05/2011 03:00 | Winner: Cruz Azul | ||||
| 1st(1st leg) | CF Monterrey | - | Pumas UNAM | 3:1 (2:0) | ||
| 2nd (2nd leg) | Pumas UNAM | - | CF Monterrey | 2:0 (1:0) | ||
| 1st(1st leg): 06/05/2011 01:00 | 2nd (2nd leg): 08/05/2011 18:00 | Winner: Pumas UNAM | ||||
| 1st(1st leg) | CF América | - | Monarcas Morelia | 1:2 (0:1) | ||
| 2nd (2nd leg) | Monarcas Morelia | - | CF América | 3:2 (1:1) | ||
| 1st(1st leg): 06/05/2011 03:00 | 2nd (2nd leg): 09/05/2011 02:00 | Winner: Monarcas Morelia | ||||
