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| 1st(1st leg) | Cruz Azul | - | Club León | 2:1 (1:0) | ||
| 2nd (2nd leg) | Club León | - | Cruz Azul | 3:0 (2:0) | ||
| 1st(1st leg): 15/11/2012 01:00 | 2nd (2nd leg): 18/11/2012 01:00 | Winner: Club León | ||||
| 1st(1st leg) | Monarcas Morelia | - | CF América | 0:2 (0:0) | ||
| 2nd (2nd leg) | CF América | - | Monarcas Morelia | 1:2 (1:2) | ||
| 1st(1st leg): 15/11/2012 03:00 | 2nd (2nd leg): 17/11/2012 23:00 | Winner: CF América | ||||
| 1st(1st leg) | CF Monterrey | - | Club Tijuana | 0:1 (0:0) | ||
| 2nd (2nd leg) | Club Tijuana | - | CF Monterrey | 1:1 (0:0) | ||
| 1st(1st leg): 16/11/2012 01:00 | 2nd (2nd leg): 19/11/2012 00:30 | Winner: Club Tijuana | ||||
| 1st(1st leg) | Deportivo Guadalajara | - | Deportivo Toluca | 1:2 (0:2) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | Deportivo Guadalajara | 3:1 (0:0) | ||
| 1st(1st leg): 16/11/2012 03:00 | 2nd (2nd leg): 18/11/2012 18:00 | Winner: Deportivo Toluca | ||||
