 |
 |
|
|
| 23/09/2021 | 01:06 | CF Monterrey | - | Deportivo Toluca | 2:0 (1:0) | |
| 28/09/2021 | 23:00 | Club Necaxa | - | Club Tijuana | 3:0 (0:0) | |
| 29/09/2021 | 01:00 | Mazatlán FC | - | FC Juárez | 3:1 (2:0) | |
| 03:00 | Atlas Guadalajara | - | Puebla FC | 0:1 (0:1) | ||
| 03:05 | CF Pachuca | - | CF América | 1:1 (1:1) | ||
| 23:00 | Atlético San Luis | - | UANL Tigres | 0:3 (0:1) | ||
| 30/09/2021 | 03:15 | Gallos Blancos | - | Deportivo Guadalajara | 1:0 (0:0) | |
| 04/11/2021 | 03:00 | Cruz Azul | - | Club León | 0:1 (0:1) | |
| 05/11/2021 | 01:00 | Pumas UNAM | - | Santos Laguna | 0:3 (0:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 11 | 6 | 4 | 1 | 14:7 | 7 | 22 |
| 2 |
|
CF Monterrey | 11 | 5 | 5 | 1 | 17:9 | 8 | 20 |
| 3 |
|
Deportivo Toluca | 11 | 6 | 2 | 3 | 18:15 | 3 | 20 |
| 4 |
|
Atlas Guadalajara | 11 | 5 | 4 | 2 | 12:5 | 7 | 19 |
| 5 |
|
Club León | 11 | 5 | 3 | 3 | 14:12 | 2 | 18 |
| 6 |
|
UANL Tigres | 11 | 4 | 5 | 2 | 17:11 | 6 | 17 |
| 7 |
|
Atlético San Luis | 11 | 4 | 5 | 2 | 16:14 | 2 | 17 |
| 8 |
|
Santos Laguna | 11 | 3 | 6 | 2 | 15:9 | 6 | 15 |
| 9 |
|
Cruz Azul | 11 | 3 | 5 | 3 | 13:10 | 3 | 14 |
| 10 |
|
Deportivo Guadalajara | 11 | 3 | 5 | 3 | 8:9 | -1 | 14 |
| 11 |
|
Mazatlán FC | 11 | 3 | 5 | 3 | 14:17 | -3 | 14 |
| 12 |
|
CF Pachuca | 11 | 3 | 3 | 5 | 12:11 | 1 | 12 |
| 13 |
|
Club Necaxa | 11 | 4 | 0 | 7 | 12:16 | -4 | 12 |
| 14 |
|
Puebla FC | 11 | 2 | 6 | 3 | 9:13 | -4 | 12 |
| 15 |
|
Gallos Blancos | 11 | 2 | 4 | 5 | 5:10 | -5 | 10 |
| 16 |
|
FC Juárez | 11 | 2 | 3 | 6 | 9:17 | -8 | 9 |
| 17 |
|
Pumas UNAM | 11 | 1 | 5 | 5 | 6:15 | -9 | 8 |
| 18 |
|
Club Tijuana | 11 | 1 | 4 | 6 | 9:20 | -11 | 7 |
| Playoffs | |
| Playoffs |
