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| 1st(1st leg) | UANL Tigres | - | Santos Laguna | 2:2 | ||
| 2nd (2nd leg) | Santos Laguna | - | UANL Tigres | 1:1 | ||
| 1st(1st leg): 10/05/2018 16:00 | 2nd (2nd leg): 13/05/2018 15:00 | Winner: Santos Laguna | ||||
| 1st(1st leg) | CF Pachuca | - | CF América | 2:2 | ||
| 2nd (2nd leg) | CF América | - | CF Pachuca | 0:3 | ||
| 1st(1st leg): 10/05/2018 16:30 | 2nd (2nd leg): 13/05/2018 16:00 | Winner: CF Pachuca | ||||
