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| 1st(1st leg) | Santos Laguna | - | UANL Tigres | 0:1 (0:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | Santos Laguna | 1:1 (0:0) | ||
| 1st(1st leg): 28/11/2018 15:00 | 2nd (2nd leg): 01/12/2018 17:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | CF Monterrey | - | Deportivo Guadalajara | 0:1 (0:1) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF Monterrey | 2:0 (0:0) | ||
| 1st(1st leg): 28/11/2018 16:00 | 2nd (2nd leg): 01/12/2018 15:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Atlas Guadalajara | - | CF Pachuca | 2:1 (1:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | Atlas Guadalajara | 1:2 (0:1) | ||
| 1st(1st leg): 28/11/2018 17:30 | 2nd (2nd leg): 01/12/2018 16:00 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | Pumas UNAM | - | CF América | 1:2 (0:2) | ||
| 2nd (2nd leg) | CF América | - | Pumas UNAM | 0:0 (0:0) | ||
| 1st(1st leg): 29/11/2018 16:00 | 2nd (2nd leg): 02/12/2018 15:00 | Winner: CF América | ||||
