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| 1st(1st leg) | CF Monterrey | - | Pumas UNAM | 2:0 (1:0) | ||
| 2nd (2nd leg) | Pumas UNAM | - | CF Monterrey | 2:0 (0:0) | ||
| 1st(1st leg): 08/05/2019 15:00 | 2nd (2nd leg): 11/05/2019 18:00 | |||||
| 1st(1st leg) | Club Necaxa | - | Atlas Guadalajara | 1:2 (0:2) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | Club Necaxa | 6:1 (2:1) | ||
| 1st(1st leg): 08/05/2019 15:00 | 2nd (2nd leg): 11/05/2019 15:00 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | CF Pachuca | - | Monarcas Morelia | 1:1 (0:0) | ||
| 2nd (2nd leg) | Monarcas Morelia | - | CF Pachuca | 1:1 (1:0) | ||
| 1st(1st leg): 08/05/2019 16:00 | 2nd (2nd leg): 11/05/2019 16:00 | |||||
| 1st(1st leg) | CF América | - | Santos Laguna | 0:0 (0:0) | ||
| 2nd (2nd leg) | Santos Laguna | - | CF América | 2:1 (0:0) | ||
| 1st(1st leg): 09/05/2019 15:00 | 2nd (2nd leg): 12/05/2019 15:00 | Winner: Santos Laguna | ||||
