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| 1st(1st leg) | Pumas UNAM | - | Club Necaxa | 2:1 (1:1) | ||
| 2nd (2nd leg) | Club Necaxa | - | Pumas UNAM | 3:1 (1:1) | ||
| 1st(1st leg): 25/11/2020 18:00 | 2nd (2nd leg): 28/11/2020 16:00 | Winner: Club Necaxa | ||||
| 1st(1st leg) | Club Tijuana | - | Atlas Guadalajara | 1:1 (1:0) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | Club Tijuana | 4:0 (3:0) | ||
| 1st(1st leg): 26/11/2020 03:00 | 2nd (2nd leg): 28/11/2020 15:00 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | Deportivo Toluca | - | Deportivo Guadalajara | 3:1 (2:1) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Deportivo Toluca | 3:2 (1:1) | ||
| 1st(1st leg): 26/11/2020 17:30 | 2nd (2nd leg): 29/11/2020 17:15 | Winner: Deportivo Toluca | ||||
| 1st(1st leg) | Puebla FC | - | CF Pachuca | 0:3 (0:1) | ||
| 2nd (2nd leg) | CF Pachuca | - | Puebla FC | 2:5 (1:3) | ||
| 1st(1st leg): 26/11/2020 17:45 | 2nd (2nd leg): 29/11/2020 16:00 | Winner: Puebla FC | ||||
