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| 1st(1st leg) | CF Pachuca | - | Club Necaxa | 1:2 (1:1) | ||
| 2nd (2nd leg) | Club Necaxa | - | CF Pachuca | 3:6 (1:1) | ||
| 1st(1st leg): 25/11/2021 15:30 | 2nd (2nd leg): 28/11/2021 15:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Atlas Guadalajara | - | CF América | 3:0 (2:0) | ||
| 2nd (2nd leg) | CF América | - | Atlas Guadalajara | 3:2 (1:0) | ||
| 1st(1st leg): 25/11/2021 17:30 | 2nd (2nd leg): 28/11/2021 17:00 | Winner: Atlas Guadalajara | ||||
