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| 1st(1st leg) | CF América | - | Pumas UNAM | 1:0 (1:0) | ||
| 2nd (2nd leg) | Pumas UNAM | - | CF América | 0:1 (0:1) | ||
| 1st(1st leg): 23/04/2025 17:00 | 2nd (2nd leg): 26/04/2025 17:00 | Winner: CF América | ||||
| 1st(1st leg) | Santos Laguna | - | UANL Tigres | 2:2 (1:1) | ||
| 2nd (2nd leg) | UANL Tigres | - | Santos Laguna | 3:1 (1:0) | ||
| 1st(1st leg): 24/04/2025 16:00 | 2nd (2nd leg): 27/04/2025 16:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Atlas Guadalajara | - | Deportivo Toluca | 2:2 (1:1) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | Atlas Guadalajara | 3:1 (1:1) | ||
| 1st(1st leg): 24/04/2025 16:00 | 2nd (2nd leg): 27/04/2025 16:00 | Winner: Deportivo Toluca | ||||
| 1st(1st leg) | Deportivo Guadalajara | - | CF Pachuca | 0:1 (0:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | Deportivo Guadalajara | 2:3 (1:2) | ||
| 1st(1st leg): 24/04/2025 17:00 | 2nd (2nd leg): 27/04/2025 17:00 | Winner: Deportivo Guadalajara | ||||
