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| 1st(1st leg) | UANL Tigres | - | CF América | 0:2 (0:1) | ||
| 2nd (2nd leg) | CF América | - | UANL Tigres | 3:1 (1:0) | ||
| 1st(1st leg): 19/05/2022 01:00 | 2nd (2nd leg): 21/05/2022 16:00 | Winner: CF América | ||||
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| 1st(1st leg) | UANL Tigres | - | CF América | 0:2 (0:1) | ||
| 2nd (2nd leg) | CF América | - | UANL Tigres | 3:1 (1:0) | ||
| 1st(1st leg): 19/05/2022 01:00 | 2nd (2nd leg): 21/05/2022 16:00 | Winner: CF América | ||||
