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| 1st(1st leg) | CF Pachuca | - | CF Monterrey | 3:0 (3:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | CF Pachuca | 1:1 (1:1) | ||
| 1st(1st leg): 23/04/2025 16:15 | 2nd (2nd leg): 26/04/2025 16:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Santos Laguna | - | Cruz Azul | 1:1 (0:1) | ||
| 2nd (2nd leg) | Cruz Azul | - | Santos Laguna | 2:4 (1:2) | ||
| 1st(1st leg): 23/04/2025 18:00 | 2nd (2nd leg): 26/04/2025 16:00 | Winner: Santos Laguna | ||||
| 1st(1st leg) | Atlético San Luis | - | Deportivo Toluca | 0:2 (0:1) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | Atlético San Luis | 2:0 (2:0) | ||
| 1st(1st leg): 24/04/2025 01:00 | 2nd (2nd leg): 26/04/2025 16:00 | Winner: Deportivo Toluca | ||||
| 1st(1st leg) | Club Necaxa | - | FC Juárez | 0:0 (0:0) | ||
| 2nd (2nd leg) | FC Juárez | - | Club Necaxa | 1:0 (0:0) | ||
| 1st(1st leg): 24/04/2025 16:00 | 2nd (2nd leg): 27/04/2025 16:00 | Winner: FC Juárez | ||||
