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| 1st(1st leg) | Metalurg Skopje | - | FK Turnovo | 3:3 | ||
| 2nd (2nd leg) | FK Turnovo | - | Metalurg Skopje | 0:1 | ||
| 1st(1st leg): 09/09/2012 14:30 | 2nd (2nd leg): 26/09/2012 14:00 | Winner: Metalurg Skopje | ||||
| 1st(1st leg) | Lokomotiva Skopje | - | FK Teteks | 0:2 | ||
| 2nd (2nd leg) | FK Teteks | - | Lokomotiva Skopje | 7:0 (2:0) | ||
| 1st(1st leg): 09/09/2012 14:30 | 2nd (2nd leg): 26/09/2012 14:00 | Winner: FK Teteks | ||||
| 1st(1st leg) | KF Shkëndija 79 | - | FK Bregalnica Štip | 1:0 | ||
| 2nd (2nd leg) | FK Bregalnica Štip | - | KF Shkëndija 79 | 0:1 | ||
| 1st(1st leg): 09/09/2012 14:30 | 2nd (2nd leg): 26/09/2012 14:00 | Winner: KF Shkëndija 79 | ||||
| 1st(1st leg) | KF Bashkimi | - | Sileks Kratovo | 0:1 | ||
| 2nd (2nd leg) | Sileks Kratovo | - | KF Bashkimi | 3:0 | ||
| 1st(1st leg): 09/09/2012 14:30 | 2nd (2nd leg): 26/09/2012 14:00 | Winner: Sileks Kratovo | ||||
| 1st(1st leg) | FK Pelister | - | Babi Štip | 5:0 | ||
| 2nd (2nd leg) | Babi Štip | - | FK Pelister | 1:1 (1:1) | ||
| 1st(1st leg): 09/09/2012 14:30 | 2nd (2nd leg): 27/09/2012 14:00 | Winner: FK Pelister | ||||
| 1st(1st leg) | FK Viktorija | - | FK Drita | 0:0 | ||
| 2nd (2nd leg) | FK Drita | - | FK Viktorija | 2:0 | ||
| 1st(1st leg): 09/09/2012 14:30 | 2nd (2nd leg): 26/09/2012 14:00 | Winner: FK Drita | ||||
| 1st(1st leg) | 11 Oktomvri | - | FK Renova | 0:5 | ||
| 2nd (2nd leg) | FK Renova | - | 11 Oktomvri | 5:0 | ||
| 1st(1st leg): 09/09/2012 14:30 | 2nd (2nd leg): 26/09/2012 14:00 | Winner: FK Renova | ||||
| 1st(1st leg) | Vardar Skopje | - | FK Gorno Lisiče | 2:0 (2:0) | ||
| 2nd (2nd leg) | FK Gorno Lisiče | - | Vardar Skopje | 1:2 | ||
| 1st(1st leg): 19/09/2012 19:00 | 2nd (2nd leg): 26/09/2012 14:00 | Winner: Vardar Skopje | ||||
