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| 20/11/2021 | 11:30 | SBV Excelsior | - | Alphense Boys | 2:1 (2:1) | |
| 13:30 | PEC Zwolle | - | FC Emmen | 3:1 (0:1) | ||
| 13:30 | De Graafschap | - | Roda JC Kerkrade | 3:1 (0:0) | ||
| 14:00 | Willem II | - | Vitesse | 4:1 (1:1) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
PEC Zwolle | 10 | 7 | 1 | 2 | 21:8 | 13 | 22 |
| 2 |
|
Willem II | 10 | 7 | 1 | 2 | 23:11 | 12 | 22 |
| 3 |
|
De Graafschap | 10 | 5 | 3 | 2 | 21:12 | 9 | 18 |
| 4 |
|
SBV Excelsior | 10 | 4 | 1 | 5 | 10:10 | 0 | 13 |
| 5 |
|
Roda JC Kerkrade | 10 | 3 | 2 | 5 | 14:20 | -6 | 11 |
| 6 |
|
Alphense Boys | 10 | 3 | 1 | 6 | 10:20 | -10 | 10 |
| 7 |
|
FC Emmen | 10 | 2 | 3 | 5 | 13:18 | -5 | 9 |
| 8 |
|
Vitesse | 10 | 2 | 2 | 6 | 9:22 | -13 | 8 |
| Promotion | |
| Relegation |
