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| 04/03/2022 | 19:45 | Cliftonville FC | - | Coleraine FC | 2:1 | |
| 05/03/2022 | 15:00 | Ballymena United | - | Larne FC | 4:3 pso | |
| 15:00 | Crusaders FC | - | Dungannon Swifts | 4:2 | ||
| 15:00 | Glentoran FC | - | Newry City FC | 0:1 dec. |
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| 04/03/2022 | 19:45 | Cliftonville FC | - | Coleraine FC | 2:1 | |
| 05/03/2022 | 15:00 | Ballymena United | - | Larne FC | 4:3 pso | |
| 15:00 | Crusaders FC | - | Dungannon Swifts | 4:2 | ||
| 15:00 | Glentoran FC | - | Newry City FC | 0:1 dec. |
