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| 02/10/2011 | 20:30 | Club Nacional | - | 3 de Febrero | 2:0 (1:0) | |
| 20:30 | Independiente CG | - | Libertad | 1:1 (1:0) | ||
| 20:30 | Sportivo Luqueño | - | General Caballero ZC | 1:4 (1:2) | ||
| 21:00 | Tacuary | - | Guaraní | 1:2 (1:0) | ||
| 23:10 | Cerro Porteño | - | Sol de América | 2:0 (1:0) | ||
| 03/10/2011 | 22:30 | Club Rubio Ñu | - | Club Olimpia | 1:1 (1:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Nacional | 11 | 7 | 2 | 2 | 16:8 | 8 | 23 |
| 2 |
|
Libertad | 11 | 6 | 4 | 1 | 20:9 | 11 | 22 |
| 3 |
|
Cerro Porteño | 11 | 5 | 4 | 2 | 17:11 | 6 | 19 |
| 4 |
|
Club Olimpia | 11 | 5 | 3 | 3 | 22:16 | 6 | 18 |
| 5 |
|
Guaraní | 11 | 5 | 2 | 4 | 17:16 | 1 | 17 |
| 6 |
|
Independiente CG | 11 | 3 | 6 | 2 | 11:10 | 1 | 15 |
| 7 |
|
Club Rubio Ñu | 11 | 3 | 4 | 4 | 12:14 | -2 | 13 |
|
Tacuary | 11 | 3 | 4 | 4 | 12:14 | -2 | 13 | |
| 9 |
|
Sportivo Luqueño | 11 | 3 | 3 | 5 | 9:14 | -5 | 12 |
| 10 |
|
Sol de América | 11 | 2 | 4 | 5 | 12:15 | -3 | 10 |
| 11 |
|
General Caballero ZC | 11 | 3 | 1 | 7 | 14:25 | -11 | 10 |
| 12 |
|
3 de Febrero | 11 | 2 | 1 | 8 | 13:23 | -10 | 7 |
| Copa Libertadores |
