 |
 |
|
|
| 10/05/2022 | 15:00 | 12 de Octubre de Itauguá | - | Club Nacional | 1:2 (0:2) | |
| 23:00 | General Caballero DJLM | - | Sportivo Ameliano | 0:3 (0:1) | ||
| 11/05/2022 | 01:00 | Libertad | - | Tacuary | 3:0 (1:0) | |
| 23:00 | Club Olimpia | - | Sol de América | 1:0 (0:0) | ||
| 12/05/2022 | 01:15 | Cerro Porteño | - | Guaireña FC | 0:0 (0:0) | |
| 01:15 | Resistencia SC | - | Guaraní | 1:2 (1:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Libertad | 15 | 12 | 2 | 1 | 34:12 | 22 | 38 |
| 2 |
|
Cerro Porteño | 15 | 11 | 2 | 2 | 27:9 | 18 | 35 |
| 3 |
|
Club Olimpia | 15 | 8 | 3 | 4 | 20:14 | 6 | 27 |
| 4 |
|
Resistencia SC | 15 | 7 | 5 | 3 | 28:22 | 6 | 26 |
| 5 |
|
Club Nacional | 15 | 6 | 2 | 7 | 19:24 | -5 | 20 |
| 6 |
|
Guaraní | 15 | 5 | 3 | 7 | 18:20 | -2 | 18 |
| 7 |
|
Sol de América | 15 | 5 | 3 | 7 | 15:20 | -5 | 18 |
| 8 |
|
Tacuary | 15 | 5 | 2 | 8 | 12:17 | -5 | 17 |
| 9 |
|
Guaireña FC | 15 | 4 | 4 | 7 | 13:19 | -6 | 16 |
| 10 |
|
Sportivo Ameliano | 15 | 4 | 1 | 10 | 17:25 | -8 | 13 |
| 11 |
|
12 de Octubre de Itauguá | 15 | 2 | 7 | 6 | 13:25 | -12 | 13 |
| 12 |
|
General Caballero DJLM | 15 | 2 | 4 | 9 | 12:21 | -9 | 10 |
| Copa Libertadores |
