| 1st(1st leg) | Sportivo Ameliano | - | Sportivo Luqueño | 3:2 (1:1) | ||
| 2nd (2nd leg) | Sportivo Luqueño | - | Sportivo Ameliano | 1:1 (0:1) | ||
| 1st(1st leg): 07/12/2021 22:30 | 2nd (2nd leg): 11/12/2021 22:30 | Winner: Sportivo Ameliano | ||||
| 1st(1st leg) | Sportivo Ameliano | - | Sportivo Luqueño | 3:2 (1:1) | ||
| 2nd (2nd leg) | Sportivo Luqueño | - | Sportivo Ameliano | 1:1 (0:1) | ||
| 1st(1st leg): 07/12/2021 22:30 | 2nd (2nd leg): 11/12/2021 22:30 | Winner: Sportivo Ameliano | ||||
