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| 1st(1st leg) | Platense Zacatecoluca | - | Alianza | 1:0 (0:0) | ||
| 2nd (2nd leg) | Alianza | - | Platense Zacatecoluca | 3:1 (1:1) | ||
| 1st(1st leg): 18/05/2022 21:30 | 2nd (2nd leg): 22/05/2022 22:15 | Winner: Alianza | ||||
| 1st(1st leg) | Isidro Metapán | - | CD Águila | 1:2 (0:1) | ||
| 2nd (2nd leg) | CD Águila | - | Isidro Metapán | 2:1 (1:0) | ||
| 1st(1st leg): 19/05/2022 02:30 | 2nd (2nd leg): 22/05/2022 02:00 | Winner: CD Águila | ||||
