 |
 |
|
| 1st(1st leg) | Jocoro FC | - | CD Águila | 1:2 (1:1) | ||
| 2nd (2nd leg) | CD Águila | - | Jocoro FC | 1:1 (1:0) | ||
| 1st(1st leg): 10/05/2022 22:15 | 2nd (2nd leg): 15/05/2022 02:00 | Winner: CD Águila | ||||
| 1st(1st leg) | FAS | - | Platense Zacatecoluca | 0:1 (0:0) | ||
| 2nd (2nd leg) | Platense Zacatecoluca | - | FAS | 2:1 (1:1) | ||
| 1st(1st leg): 10/05/2022 22:15 | 2nd (2nd leg): 15/05/2022 22:00 | Winner: Platense Zacatecoluca | ||||
| 1st(1st leg) | Luis Ángel Firpo | - | Alianza | 1:2 (0:0) | ||
| 2nd (2nd leg) | Alianza | - | Luis Ángel Firpo | 2:1 (1:1) | ||
| 1st(1st leg): 12/05/2022 02:00 | 2nd (2nd leg): 15/05/2022 22:15 | Winner: Alianza | ||||
| 1st(1st leg) | Isidro Metapán | - | AD Chalatenango | 1:0 (1:0) | ||
| 2nd (2nd leg) | AD Chalatenango | - | Isidro Metapán | 1:2 (0:0) | ||
| 1st(1st leg): 12/05/2022 02:15 | 2nd (2nd leg): 15/05/2022 02:00 | Winner: Isidro Metapán | ||||
