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| 13/10/2021 | 13:00 | Radnik Surdulica | - | FK Radnički 1923 | 2:0 (2:0) | |
| 15:30 | Partizan | - | FK Trayal | 3:0 (1:0) | ||
| 14/10/2021 | 16:00 | FK Metalac | - | FK Žarkovo | 3:2 (2:1) | |
| 27/10/2021 | 13:00 | FK Novi Pazar | - | Budućnost Dobanovci | 1:0 (0:0) | |
| 13:00 | Sloga Požega | - | FK Rad Beograd | 0:1 (0:1) | ||
| 13:30 | FK Loznica | - | FK Čukarički | 1:0 (1:0) | ||
| 13:30 | Železničar Pančevo | - | FK Napredak | 0:1 (0:1) | ||
| 13:30 | Radnički Niš | - | Dinamo Vranje | 1:0 (0:0) | ||
| 13:30 | OFK Bačka | - | Proleter Novi Sad | 3:2 (0:1) pso | ||
| 13:30 | FK Zlatibor | - | TSC Bačka Topola | 0:4 (0:2) | ||
| 13:30 | Radnički Beograd | - | FK Voždovac | 2:1 (2:0) | ||
| 14:00 | FK Javor | - | Mačva Šabac | 2:1 (2:1) | ||
| 15:00 | Vojvodina | - | FK Jagodina | 5:1 (2:1) | ||
| 15:00 | Spartak Subotica | - | Dubočica Leskovac | 4:5 (1:1) pso | ||
| 16:00 | Mladost Lučani | - | FK Kolubara | 2:3 (0:1) | ||
| 18/11/2021 | 12:00 | FK Inđija | - | Crvena Zvezda | 0:1 (0:1) |
