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| 20/11/2010 | 12:00 | Vojvodina | - | FK Inđija | 2:0 (2:0) | |
| 12:00 | FK Smederevo | - | Spartak Zlatibor Voda | 0:0 (0:0) | ||
| 12:00 | BSK Borča | - | OFK Beograd | 1:1 (0:0) | ||
| 12:00 | FK Javor | - | Hajduk Rodić | 0:0 (0:0) | ||
| 12:00 | FK Čukarički | - | Partizan | 2:4 (0:3) | ||
| 12:00 | FK Metalac | - | FK Sloboda Point Sevojno | 3:2 (1:2) | ||
| 21/11/2010 | 12:00 | FK Jagodina | - | FK Rad Beograd | 1:1 (1:0) | |
| 17:00 | Crvena Zvezda | - | Borac Čačak | 2:0 (1:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Partizan | 13 | 11 | 1 | 1 | 31:9 | 22 | 34 |
| 2 |
|
Crvena Zvezda | 13 | 10 | 1 | 2 | 17:5 | 12 | 31 |
| 3 |
|
Vojvodina | 13 | 8 | 4 | 1 | 17:2 | 15 | 28 |
| 4 |
|
FK Rad Beograd | 13 | 7 | 4 | 2 | 15:7 | 8 | 25 |
| 5 |
|
FK Sloboda Point Sevojno | 13 | 5 | 5 | 3 | 14:11 | 3 | 20 |
| 6 |
|
FK Jagodina | 13 | 5 | 4 | 4 | 12:11 | 1 | 19 |
| 7 |
|
Spartak Zlatibor Voda | 13 | 4 | 6 | 3 | 13:10 | 3 | 18 |
| 8 |
|
FK Smederevo | 13 | 3 | 8 | 2 | 13:10 | 3 | 17 |
| 9 |
|
OFK Beograd | 13 | 4 | 4 | 5 | 11:12 | -1 | 16 |
| 10 |
|
FK Javor | 13 | 3 | 6 | 4 | 9:11 | -2 | 15 |
| 11 |
|
BSK Borča | 13 | 3 | 5 | 5 | 8:15 | -7 | 14 |
| 12 |
|
FK Inđija | 13 | 3 | 4 | 6 | 11:16 | -5 | 13 |
| 13 |
|
Borac Čačak | 13 | 2 | 6 | 5 | 6:15 | -9 | 12 |
| 14 |
|
FK Metalac | 13 | 2 | 2 | 9 | 8:19 | -11 | 8 |
| 15 |
|
Hajduk Rodić | 13 | 1 | 3 | 9 | 7:18 | -11 | 6 |
| 16 |
|
FK Čukarički | 13 | 0 | 3 | 10 | 4:25 | -21 | 3 |
| Champions League Quali. | |
| Europa League | |
| Relegation |
