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| 31/08/2021 | 13:00 | Epitsentr Dunaivtsi | - | Niva Ternopil | 1:0 | |
| 14:30 | FK Bukovina | - | Prykarpattya Ivano-Frankivsk | 2:4 pso | ||
| 14:30 | FC Nikopol-NPHU | - | Tavriya Simferopol | 0:3 | ||
| 14:30 | Balkany Zorya | - | FK VPK-Ahro Shevchenkivka | 1:3 aet | ||
| 15:00 | FC Chernigov | - | Alians Lypova Dolyna | 1:5 | ||
| 16:00 | Metalurg Zaporizhya | - | Hirnyk-Sport | 2:3 | ||
| 17:00 | Karpaty Lviv | - | Volyn Lutsk | 2:3 aet | ||
| 17:00 | FC LNZ Cherkasy | - | Olimpik Donetsk | 2:1 | ||
| 17:00 | FK Obolon | - | Polissya Zhytomyr | 1:0 | ||
| 01/09/2021 | 14:30 | Skoruk Tomakivka | - | Metalist 1925 Kharkiv | 0:3 | |
| 15:00 | MFK Mikolaiv | - | FK Vovchansk | 4:1 |
