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| 24/08/2022 | 00:00 | Rocha | - | Rentistas | 0:3 (0:1) | |
| 00:30 | Juventud de Colonia | - | River Plate | 1:2 (0:1) | ||
| 31/08/2022 | 17:45 | La Luz | - | Fénix | 2:1 (1:1) | |
| 19:00 | Uruguay Montevideo | - | Montevideo City Torque | 2:4 (1:3) | ||
| 19:00 | Juventud de Las Piedras | - | Albion | 4:5 (0:0, 0:0, 0:0) pso | ||
| 19:15 | Progreso | - | Danubio | 4:3 (2:0, 2:2, 2:2) pso | ||
| 01/09/2022 | 00:00 | Durazno | - | Plaza Colonia | 1:3 (1:1) | |
| 00:15 | Central Español | - | Liverpool | 1:2 (0:0) | ||
| 17:45 | Mar de Fondo | - | Cerrito | 0:1 (0:0) | ||
| 06/09/2022 | 19:00 | Rampla Juniors | - | Deportivo Maldonado | 2:1 (1:1) | |
| 07/09/2022 | 00:00 | Universitario de Salto | - | Montevideo Wanderers | 1:3 (0:3) | |
| 17:45 | Racing | - | Defensor Sporting | 0:1 (0:0) | ||
| 08/09/2022 | 00:00 | Miramar Misiones | - | Nacional | 0:1 (0:0) | |
| 00:00 | Deportivo Colonia | - | Cerro Largo | 0:2 (0:0) | ||
| 00:00 | Central | - | Boston River | 0:2 (0:2) | ||
| 09/09/2022 | 00:00 | Colón | - | Peñarol | 0:2 (0:0) |
