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| 1st(1st leg) | Miramar Misiones | - | CA Cerro | 0:2 (0:2) | ||
| 2nd (2nd leg) | CA Cerro | - | Miramar Misiones | 1:3 (1:0) | ||
| 1st(1st leg): 01/10/2022 19:00 | 2nd (2nd leg): 08/10/2022 17:30 | Winner: Miramar Misiones | ||||
| 1st(1st leg) | Rampla Juniors | - | Uruguay Montevideo | 1:0 (1:0) | ||
| 2nd (2nd leg) | Uruguay Montevideo | - | Rampla Juniors | 1:1 (0:1) | ||
| 1st(1st leg): 02/10/2022 17:30 | 2nd (2nd leg): 09/10/2022 17:30 | Winner: Rampla Juniors | ||||
