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| 1st(1st leg) | Seattle Sounders | - | Real Salt Lake | 0:0 (0:0) | ||
| 2nd (2nd leg) | Real Salt Lake | - | Seattle Sounders | 0:1 (0:0) | ||
| 1st(1st leg): 03/11/2012 02:00 | 2nd (2nd leg): 09/11/2012 03:00 | Winner: Seattle Sounders | ||||
| 1st(1st leg) | D.C. United | - | New York RB | 1:1 (0:0) | ||
| 2nd (2nd leg) | New York RB | - | D.C. United | 0:1 (0:0) | ||
| 1st(1st leg): 04/11/2012 00:00 | 2nd (2nd leg): 09/11/2012 00:30 | Winner: D.C. United | ||||
| 1st(1st leg) | Houston Dynamo | - | Sporting Kansas City | 2:0 (1:0) | ||
| 2nd (2nd leg) | Sporting Kansas City | - | Houston Dynamo | 1:0 (0:0) | ||
| 1st(1st leg): 04/11/2012 20:30 | 2nd (2nd leg): 08/11/2012 02:00 | Winner: Houston Dynamo | ||||
| 1st(1st leg) | Los Angeles Galaxy | - | San Jose Earthquakes | 0:1 (0:0) | ||
| 2nd (2nd leg) | San Jose Earthquakes | - | Los Angeles Galaxy | 1:3 (0:3) | ||
| 1st(1st leg): 05/11/2012 02:00 | 2nd (2nd leg): 08/11/2012 04:00 | Winner: Los Angeles Galaxy | ||||
