| Europa League | M. | W | D | L | goals | |||
| at home | 1 | 0 | 1 | 0 | 1 | : | 1 | |
| Away | 2 | 0 | 0 | 2 | 4 | : | 6 | |
| ∑ | 3 | 0 | 1 | 2 | 5 | : | 7 | |
| overall | M. | W | D | L | goals | |||
| at home | 1 | 0 | 1 | 0 | 1 | : | 1 | |
| Away | 2 | 0 | 0 | 2 | 4 | : | 6 | |
| Neutral Place | 0 | 0 | 0 | 0 | 0 | : | 0 | |
| ∑ | 3 | 0 | 1 | 2 | 5 | : | 7 | |
| Europa League | |||||
| 2008/2009 | Group A | Manchester City | - | FC Twente | 3:2 (1:1) |
| 1978/1979 | 1. Round | Manchester City | - | FC Twente '65 | 3:2 (1:0) |
| 1978/1979 | 1. Round | FC Twente '65 | - | Manchester City | 1:1 (0:1) |
|
For games that were decided on penalties the score after 120 minutes will be included in the ranking |
Netherlands 
![FC Twente [Women]](https://s.hs-data.com/bilder/wappen/mini/13616.gif?fallback=png "FC Twente [Women]"){kind=small}
![Twente/Heracles [U21]](https://s.hs-data.com/bilder/wappen/mini/34837.gif?fallback=png "Twente/Heracles [U21]"){kind=small}
![Twente/Heracles [U18]](https://s.hs-data.com/bilder/wappen/mini/34838.gif?fallback=png "Twente/Heracles [U18]"){kind=small}
![FC Twente [Youth]](https://s.hs-data.com/bilder/wappen/mini/14623.gif?fallback=png "FC Twente [Youth]"){kind=small}
![FC Twente [Youth B]](https://s.hs-data.com/bilder/wappen/mini/18987.gif?fallback=png "FC Twente [Youth B]"){kind=small}
![FC Twente [Youth B Women]](https://s.hs-data.com/bilder/wappen/mini/35919.gif?fallback=png "FC Twente [Youth B Women]"){kind=small}
![FC Twente [Youth C]](https://s.hs-data.com/bilder/wappen/mini/29047.gif?fallback=png "FC Twente [Youth C]"){kind=small}
