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| 03/01/2021 | Villa San Carlos | - | Almirante Brown | 3:0 | ??? | |
| 06/03/2021 | Villa San Carlos | - | Cañuelas | 1:1 | ??? | |
| 21/03/2021 | Villa San Carlos | - | Sacachispas | 5:2 | ??? | |
| 04/04/2021 | Villa San Carlos | - | Argentino de Quilmes | 2:1 | ??? | |
| 17/04/2021 | Villa San Carlos | - | Colegiales de Munro | 3:2 | ??? | |
| 02/05/2021 | Villa San Carlos | - | Defensores Unidos de Zárate | 1:0 | ??? | |
| 07/06/2021 | Villa San Carlos | - | Comunicaciones de Buenos Aires | 1:1 | ??? | |
| 22/06/2021 | Villa San Carlos | - | Talleres (RdE) | 0:2 | ??? | |
| 02/07/2021 | Villa San Carlos | - | Deportivo Merlo | 0:0 | ??? | |
| 24/07/2021 | Villa San Carlos | - | Acassuso | 0:2 | ??? | |
| 07/08/2021 | Villa San Carlos | - | Justo José de Urquiza | 3:1 | ??? | |
| 24/08/2021 | Villa San Carlos | - | CA Los Andes | 1:1 | ??? | |
| 04/09/2021 | Villa San Carlos | - | Fénix | 1:1 | ??? | |
| 25/09/2021 | Villa San Carlos | - | Armenio | 0:0 | ??? | |
| 24/10/2021 | Villa San Carlos | - | Atlético San Miguel | 4:2 | ??? | |
| 06/11/2021 | Villa San Carlos | - | Flandria | 0:1 | ??? | |
| 21/11/2021 | Villa San Carlos | - | Armenio | 0:0 | ??? |
Argentina