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| Primera | 09/02/2021 | River Plate | - | Guaraní | 1:4 | ??? |
| Primera | 19/02/2021 | River Plate | - | Sportivo Luqueño | 1:0 | ??? |
| Primera | 05/03/2021 | River Plate | - | Guaireña FC | 0:1 | ??? |
| Primera | 13/03/2021 | River Plate | - | Club Nacional | 0:0 | ??? |
| Primera | 01/04/2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 | ??? |
| Primera | 18/04/2021 | River Plate | - | Sol de América | 0:2 | ??? |
| Primera | 04/05/2021 | River Plate | - | Libertad | 1:3 | ??? |
| Primera | 16/05/2021 | River Plate | - | Cerro Porteño | 1:1 | ??? |
| Primera | 30/05/2021 | River Plate | - | Club Olimpia | 1:2 | ??? |
| Primera | 31/07/2021 | River Plate | - | Cerro Porteño | 0:0 | ??? |
| Primera | 14/08/2021 | River Plate | - | Club Nacional | 1:0 | ??? |
| Primera | 30/08/2021 | River Plate | - | Guaraní | 1:5 | ??? |
| Primera | 18/09/2021 | River Plate | - | Libertad | 0:1 | ??? |
| Primera | 26/09/2021 | River Plate | - | Club Olimpia | 1:2 | ??? |
| Primera | 03/10/2021 | River Plate | - | Guaireña FC | 1:1 | ??? |
| Primera | 23/10/2021 | River Plate | - | Sol de América | 0:2 | ??? |
Paraguay