 |
 |
| Quarter-finals | ||||||
|---|---|---|---|---|---|---|
| 03/12/2021 | 18:45 | Cruz Azul | - | UANL Tigres | 0:4 (0:3) | |
| 04/12/2021 | 00:00 | Santos Laguna | - | Atlas Guadalajara | 2:2 (0:0) | |
| 02:00 | CF América | - | Deportivo Guadalajara | 2:1 (2:0) | ||
| 03:30 | Club Tijuana | - | CF Monterrey | 1:1 (1:0) | ||
| 06/12/2021 | 18:00 | Atlas Guadalajara | - | Santos Laguna | 2:1 (1:1) | |
| 23:00 | Deportivo Guadalajara | - | CF América | 0:0 (0:0) | ||
| 07/12/2021 | 01:00 | UANL Tigres | - | Cruz Azul | 4:0 (1:0) | |
| 03:00 | CF Monterrey | - | Club Tijuana | 1:1 (1:1) | ||
| Semi-finals | ||||||
| 10/12/2021 | 17:00 | Atlas Guadalajara | - | CF Monterrey | 1:0 (0:0) | |
| 11/12/2021 | 02:00 | CF América | - | UANL Tigres | 2:1 (0:0) | |
| 14/12/2021 | 01:00 | UANL Tigres | - | CF América | 4:0 (0:0) | |
| 03:00 | CF Monterrey | - | Atlas Guadalajara | 2:1 (0:1) | ||
| Final | ||||||
| 18/12/2021 | 03:00 | CF Monterrey | - | UANL Tigres | 2:2 (2:1) | |
| 21/12/2021 | 02:00 | UANL Tigres | - | CF Monterrey | 1:3 (0:0, 0:0, 0:0) pso | |
