1. Round
21/08/2021 FC Famalicão FC Famalicão - Rio Ave FC Rio Ave FC -:-
21/08/2021 Sporting Braga Sporting Braga - FC Vizela FC Vizela -:-
21/08/2021 Vitória Guimarães Vitória Guimarães - Académica de Coimbra Académica de Coimbra -:-
21/08/2021 Os Belenenses Os Belenenses - Portimonense SC Portimonense SC -:-
21/08/2021 CS Marítimo CS Marítimo - Sporting CP Sporting CP -:-
21/08/2021 SC Farense SC Farense - GD Estoril GD Estoril -:-
2. Round
28/08/2021 Académica de Coimbra Académica de Coimbra - FC Famalicão FC Famalicão -:-
28/08/2021 Leixões SC Leixões SC - Vitória Guimarães Vitória Guimarães -:-
28/08/2021 Rio Ave FC Rio Ave FC - Sporting Braga Sporting Braga -:-
28/08/2021 Portimonense SC Portimonense SC - SC Farense SC Farense -:-
28/08/2021 SL Benfica SL Benfica - CS Marítimo CS Marítimo -:-
28/08/2021 Sporting CP Sporting CP - Os Belenenses Os Belenenses -:-