| 1. Round | 19/09/2021 | Colima FC | - | Mazorqueros | 1:2 | ||||
| 2. Round | 25/09/2021 | Tecos Fútbol Club | - | Colima FC | 1:1 | ||||
| 3. Round | 02/10/2021 | Correcaminos UAT II | - | Colima FC | 0:0 | ||||
| 4. Round | 10/10/2021 | Colima FC | - | Leones Negros II | 2:1 | ||||
| 8. Round | 31/10/2021 | Colima FC | - | Alacranes de Durango | 1:0 | ||||
| 9. Round | 06/11/2021 | Cimarrones de Sonora II | - | Colima FC | 0:1 | ||||
| 10. Round | 11/11/2021 | Colima FC | - | Saltillo FC | 1:2 |  |
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| 11. Round | 13/11/2021 | Tritones Vallarta | - | Colima FC | 3:0 | ||||
| 12. Round | 23/11/2021 | Colima FC | - | Catedráticos Elite | 3:0 | ||||
| 13. Round | 27/11/2021 | Gavilanes de Matamoros | - | Colima FC | 3:1 |
Mexico