2. Round | 21/08/2021 | VfL Bochum | - | 1. FSV Mainz 05 | 2:0 | ||||
3. Round | 28/08/2021 | 1. FSV Mainz 05 | - | SpVgg Greuther Fürth | 3:0 | ||||
4. Round | 11/09/2021 | 1899 Hoffenheim | - | 1. FSV Mainz 05 | 0:2 | ||||
5. Round | 18/09/2021 | 1. FSV Mainz 05 | - | SC Freiburg | 0:0 | ||||
9. Round | 22/10/2021 | 1. FSV Mainz 05 | - | FC Augsburg | 4:1 | ||||
10. Round | 30/10/2021 | Arminia Bielefeld | - | 1. FSV Mainz 05 | 1:2 | ||||
11. Round | 05/11/2021 | 1. FSV Mainz 05 | - | Bor. Mönchengladbach | 1:1 | ||||
12. Round | 21/11/2021 | 1. FSV Mainz 05 | - | 1. FC Köln | 1:1 | ||||
13. Round | 26/11/2021 | VfB Stuttgart | - | 1. FSV Mainz 05 | 2:1 | ||||
14. Round | 04/12/2021 | 1. FSV Mainz 05 | - | VfL Wolfsburg | 3:0 | ||||
21. Round | 05/02/2022 | 1. FSV Mainz 05 | - | 1899 Hoffenheim | 2:0 | ||||
22. Round | 12/02/2022 | SC Freiburg | - | 1. FSV Mainz 05 | 1:1 |