| 11. Round | 14/09/2022 | Libertad | - | Tacuary | 2:0 | ||||
| 14. Round | 02/10/2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
| 15. Round | 06/10/2022 | Resistencia SC | - | Libertad | 1:0 | ||||
| 16. Round | 09/10/2022 | Libertad | - | 12 de Octubre de Itauguá | 2:2 | ||||
| 13. Round | 12/10/2022 | Club Olimpia | - | Libertad | 1:0 | ||||
| 18. Round | 23/10/2022 | Libertad | - | Club Nacional | 0:1 | ||||
| 19. Round | 27/10/2022 | Guaraní | - | Libertad | 1:2 | ||||
| 21. Round | 06/11/2022 | Libertad | - | Guaireña FC | 4:2 | ||||
| 22. Round | 12/11/2022 | Tacuary | - | Libertad | 1:0 |
Paraguay