 |
 |
|
|
| 25/10/2022 | 23:00 | Sol de América | - | Tacuary | 2:2 (1:1) | |
| 26/10/2022 | 18:00 | 12 de Octubre de Itauguá | - | Sportivo Ameliano | 4:0 (1:0) | |
| 27/10/2022 | 14:00 | Resistencia SC | - | Club Olimpia | 1:6 (0:2) | |
| 21:00 | Club Nacional | - | Guaireña FC | 3:0 (2:0) | ||
| 21:00 | Guaraní | - | Libertad | 1:2 (1:0) | ||
| 28/10/2022 | 00:00 | Cerro Porteño | - | General Caballero DJLM | 2:1 (1:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Nacional | 19 | 13 | 5 | 1 | 28:11 | 17 | 44 |
| 2 |
|
Club Olimpia | 19 | 13 | 3 | 3 | 36:17 | 19 | 42 |
| 3 |
|
Cerro Porteño | 19 | 12 | 5 | 2 | 28:12 | 16 | 41 |
| 4 |
|
Libertad | 19 | 9 | 3 | 7 | 31:24 | 7 | 30 |
| 5 |
|
Tacuary | 19 | 7 | 4 | 8 | 23:22 | 1 | 25 |
| 6 |
|
Guaireña FC | 19 | 6 | 6 | 7 | 22:24 | -2 | 24 |
| 7 |
|
General Caballero DJLM | 19 | 6 | 3 | 10 | 22:26 | -4 | 21 |
| 8 |
|
Guaraní | 19 | 5 | 5 | 9 | 19:26 | -7 | 20 |
| 9 |
|
Sportivo Ameliano | 19 | 6 | 2 | 11 | 21:29 | -8 | 20 |
| 10 |
|
Sol de América | 19 | 5 | 5 | 9 | 20:29 | -9 | 20 |
| 11 |
|
Resistencia SC | 19 | 5 | 5 | 9 | 16:30 | -14 | 20 |
| 12 |
|
12 de Octubre de Itauguá | 19 | 3 | 2 | 14 | 15:31 | -16 | 11 |
| Copa Libertadores |
