| 3. Round | 21/01/2022 | Mazatlán FC [U18] | - | Deportivo Toluca [U18] | 0:0 | ||||
| 5. Round | 12/02/2022 | Atlético San Luis [U18] | - | Deportivo Toluca [U18] | 3:4 | ||||
| 7. Round | 24/02/2022 | Gallos Blancos [U18] | - | Deportivo Toluca [U18] | 0:2 | ||||
| 8. Round | 01/03/2022 | Deportivo Toluca [U18] | - | Club Tijuana [U18] | 1:1 | ||||
| 9. Round | 04/03/2022 | Club Necaxa [U18] | - | Deportivo Toluca [U18] | 0:1 | ||||
| 11. Round | 20/03/2022 | CF América [U18] | - | Deportivo Toluca [U18] | 3:2 | ||||
| 13. Round | 09/04/2022 | Deportivo Toluca [U18] | - | Deportivo Guadalajara [U18] | 3:3 | ||||
| 15. Round | 19/04/2022 | Deportivo Toluca [U18] | - | FC Juárez [U18] | 4:0 | ||||
| 14. Round | 27/04/2022 | UANL Tigres [U18] | - | Deportivo Toluca [U18] | 1:1 | ||||
| 17. Round | 01/05/2022 | Club León [U18] | - | Deportivo Toluca [U18] | 0:0 |
Mexico