 |
 |
|
|
| 19/04/2022 | 15:00 | CF Pachuca | - | Puebla FC | 3:0 (1:0) | |
| 17:15 | Club Necaxa | - | UANL Tigres | 2:0 (1:0) | ||
| 17:15 | Deportivo Guadalajara | - | Club Tijuana | 2:2 (0:1) | ||
| 17:30 | Deportivo Toluca | - | FC Juárez | 4:0 (2:0) | ||
| 18:30 | Mazatlán FC | - | Santos Laguna | 1:2 (0:1) | ||
| 20/04/2022 | 17:00 | CF América | - | Club León | 5:1 (2:1) | |
| 17:30 | Atlético San Luis | - | Pumas UNAM | 2:1 (0:0) | ||
| 17:30 | CF Monterrey | - | Atlas Guadalajara | 0:2 (0:1) | ||
| 21/04/2022 | 17:30 | Gallos Blancos | - | Cruz Azul | 1:1 (0:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 15 | 10 | 3 | 2 | 34:16 | 18 | 43 |
| 2 |
|
Atlas Guadalajara | 15 | 9 | 5 | 1 | 26:12 | 14 | 43 |
| 3 |
|
Santos Laguna | 15 | 8 | 5 | 2 | 31:15 | 16 | 38 |
| 4 |
|
Club León | 15 | 9 | 3 | 3 | 25:21 | 4 | 37 |
| 5 |
|
Club Tijuana | 15 | 7 | 4 | 4 | 26:24 | 2 | 36 |
| 6 |
|
Deportivo Guadalajara | 15 | 7 | 5 | 3 | 30:18 | 12 | 34 |
| 7 |
|
Pumas UNAM | 15 | 7 | 3 | 5 | 23:19 | 4 | 31 |
| 8 |
|
Cruz Azul | 15 | 6 | 3 | 6 | 17:18 | -1 | 30 |
| 9 |
|
Deportivo Toluca | 15 | 5 | 6 | 4 | 24:18 | 6 | 29 |
| 10 |
|
Atlético San Luis | 15 | 7 | 2 | 6 | 23:21 | 2 | 29 |
| 11 |
|
CF Pachuca | 15 | 7 | 0 | 8 | 25:23 | 2 | 28 |
| 12 |
|
CF Monterrey | 15 | 5 | 2 | 8 | 25:33 | -8 | 28 |
| 13 |
|
UANL Tigres | 15 | 4 | 4 | 7 | 17:29 | -12 | 25 |
| 14 |
|
Club Necaxa | 15 | 5 | 2 | 8 | 21:24 | -3 | 24 |
| 15 |
|
Mazatlán FC | 15 | 2 | 4 | 9 | 15:32 | -17 | 20 |
| 16 |
|
Gallos Blancos | 15 | 3 | 2 | 10 | 10:22 | -12 | 18 |
| 17 |
|
FC Juárez | 15 | 2 | 4 | 9 | 16:28 | -12 | 17 |
| 18 |
|
Puebla FC | 15 | 1 | 5 | 9 | 13:28 | -15 | 17 |
| Playoffs |
