| 1. Round | 08/01/2022 | FC Juárez | - | Club Necaxa | 2:1 | ||||
| 2. Round | 16/01/2022 | Cruz Azul | - | FC Juárez | 1:0 | ||||
| 8. Round | 02/03/2022 | Puebla FC | - | FC Juárez | 1:1 | ||||
| 9. Round | 05/03/2022 | FC Juárez | - | Club León | 0:1 | ||||
| 5. Round | 16/03/2022 | CF Monterrey | - | FC Juárez | 3:0 |  |
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| 11. Round | 21/03/2022 | Club Tijuana | - | FC Juárez | 1:0 | ||||
| 12. Round | 03/04/2022 | FC Juárez | - | Pumas UNAM | 0:1 | ||||
| 13. Round | 10/04/2022 | CF América | - | FC Juárez | 3:0 | |
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| 17. Round | 30/04/2022 | Gallos Blancos | - | FC Juárez | 4:0 |
Mexico