| 1. Round | 09/05/2018 | Torque | - | River Plate | 2:2 | ||||
| 2. Round | 12/05/2018 | River Plate | - | Defensor Sporting | 1:0 | ||||
| 3. Round | 20/05/2018 | Peñarol | - | River Plate | 6:0 | ||||
| 4. Round | 27/05/2018 | Progreso | - | River Plate | 0:0 | ||||
| 5. Round | 30/05/2018 | River Plate | - | Boston River | 1:0 |  |
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| 6. Round | 03/06/2018 | Atenas | - | River Plate | 1:1 | |
Uruguay