| 1. Round | 25/07/2021 | Club Tijuana [U20] | - | UANL Tigres [U20] | 1:1 |  |
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| 2. Round | 31/07/2021 | Club León [U20] | - | Club Tijuana [U20] | 2:1 | |
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| 3. Round | 06/08/2021 | Club Tijuana [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 4. Round | 13/08/2021 | FC Juárez [U20] | - | Club Tijuana [U20] | 1:3 | |
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| 5. Round | 17/08/2021 | Club Tijuana [U20] | - | Puebla FC [U20] | 3:0 | ||||
| 6. Round | 22/08/2021 | CF América [U20] | - | Club Tijuana [U20] | 1:1 | ||||
| 8. Round | 10/09/2021 | Club Tijuana [U20] | - | Santos Laguna [U20] | 2:2 |  |
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| 10. Round | 24/09/2021 | Club Tijuana [U20] | - | Mazatlán FC [U20] | 3:5 | ||||
| 11. Round | 28/09/2021 | Club Necaxa [U20] | - | Club Tijuana [U20] | 2:2 | ||||
| 12. Round | 03/10/2021 | Club Tijuana [U20] | - | Cruz Azul [U20] | 0:1 | |
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| 13. Round | 14/10/2021 | Gallos Blancos [U20] | - | Club Tijuana [U20] | 3:3 | ||||
| 14. Round | 20/10/2021 | Club Tijuana [U20] | - | Deportivo Guadalajara [U20] | 1:2 | |
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| 16. Round | 28/10/2021 | Atlas Guadalajara [U20] | - | Club Tijuana [U20] | 1:1 | |
Mexico