 |
 |
|
|
| 28/10/2021 | 15:00 | Atlas Guadalajara | - | Club Tijuana | 1:1 (0:0) | |
| 29/10/2021 | 15:00 | Club Necaxa | - | Mazatlán FC | 1:1 (0:1) | |
| 16:00 | FC Juárez | - | Puebla FC | 1:1 (1:0) | ||
| 30/10/2021 | 15:00 | Gallos Blancos | - | Santos Laguna | 0:5 (0:1) | |
| 15:00 | UANL Tigres | - | Deportivo Guadalajara | 3:0 (2:0) | ||
| 18:00 | CF Pachuca | - | Pumas UNAM | 1:0 (1:0) | ||
| 31/10/2021 | 15:00 | Cruz Azul | - | CF América | 1:1 (0:0) | |
| 15:00 | Deportivo Toluca | - | Club León | 1:0 (0:0) | ||
| 15:00 | Atlético San Luis | - | CF Monterrey | 3:1 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Santos Laguna | 16 | 9 | 4 | 3 | 36:20 | 16 | 31 |
| 2 |
|
Cruz Azul | 16 | 6 | 8 | 2 | 13:8 | 5 | 26 |
| 3 |
|
Deportivo Toluca | 16 | 8 | 2 | 6 | 21:19 | 2 | 26 |
| 4 |
|
Atlas Guadalajara | 16 | 7 | 4 | 5 | 22:20 | 2 | 25 |
| 5 |
|
CF América | 16 | 6 | 6 | 4 | 23:19 | 4 | 24 |
| 6 |
|
UANL Tigres | 16 | 7 | 2 | 7 | 23:19 | 4 | 23 |
| 7 |
|
Atlético San Luis | 16 | 7 | 2 | 7 | 26:25 | 1 | 23 |
| 8 |
|
Deportivo Guadalajara | 16 | 7 | 2 | 7 | 22:25 | -3 | 23 |
| 9 |
|
CF Pachuca | 16 | 5 | 7 | 4 | 23:17 | 6 | 22 |
| 10 |
|
Mazatlán FC | 16 | 6 | 4 | 6 | 30:30 | 0 | 22 |
| 11 |
|
Puebla FC | 16 | 5 | 7 | 4 | 26:28 | -2 | 22 |
| 12 |
|
Pumas UNAM | 16 | 6 | 3 | 7 | 26:24 | 2 | 21 |
| 13 |
|
Club Necaxa | 16 | 5 | 6 | 5 | 24:25 | -1 | 21 |
| 14 |
|
Club León | 16 | 6 | 3 | 7 | 16:18 | -2 | 21 |
| 15 |
|
CF Monterrey | 16 | 5 | 4 | 7 | 25:23 | 2 | 19 |
| 16 |
|
Club Tijuana | 16 | 4 | 6 | 6 | 23:28 | -5 | 18 |
| 17 |
|
Gallos Blancos | 16 | 4 | 5 | 7 | 18:28 | -10 | 17 |
| 18 |
|
FC Juárez | 16 | 1 | 5 | 10 | 11:32 | -21 | 8 |
| Playoffs |
