| 1. Round | 17/07/2022 | Club Olimpia | - | Guaraní | 2:0 | ||||
| 2. Round | 22/07/2022 | Guaraní | - | General Caballero DJLM | 2:1 |  |
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| 3. Round | 26/07/2022 | Resistencia SC | - | Guaraní | 0:0 | ||||
| 4. Round | 31/07/2022 | Guaraní | - | 12 de Octubre de Itauguá | 0:1 | ||||
| 5. Round | 07/08/2022 | Sol de América | - | Guaraní | 1:0 | ||||
| 6. Round | 14/08/2022 | Guaraní | - | Club Nacional | 1:1 | ||||
| 7. Round | 21/08/2022 | Cerro Porteño | - | Guaraní | 1:1 | ||||
| 8. Round | 27/08/2022 | Libertad | - | Guaraní | 2:2 | ||||
| 9. Round | 02/09/2022 | Guaraní | - | Guaireña FC | 2:2 | ||||
| 10. Round | 11/09/2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 11. Round | 15/09/2022 | Guaraní | - | Sportivo Ameliano | 2:1 |  |
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| 14. Round | 03/10/2022 | Guaraní | - | Resistencia SC | 0:1 | ||||
| 15. Round | 07/10/2022 | 12 de Octubre de Itauguá | - | Guaraní | 0:1 | ||||
| 16. Round | 13/10/2022 | Guaraní | - | Sol de América | 4:1 | |
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| 17. Round | 17/10/2022 | Club Nacional | - | Guaraní | 2:0 | ||||
| 18. Round | 23/10/2022 | Guaraní | - | Cerro Porteño | 1:2 | ||||
| 19. Round | 27/10/2022 | Guaraní | - | Libertad | 1:2 | ||||
| 21. Round | 06/11/2022 | Guaraní | - | Tacuary | 2:1 | ||||
| 22. Round | 13/11/2022 | Sportivo Ameliano | - | Guaraní | 4:2 |
Paraguay