| 1. Round | 24/07/2021 | Tatran Liptovský Mikuláš | - | Slovan Bratislava | 1:4 | ||||
| 2. Round | 31/07/2021 | Slovan Bratislava | - | AS Trenčín | 2:0 | ||||
| 4. Round | 14/08/2021 | Slovan Bratislava | - | MFK Zemplín Michalovce | 3:1 |  |
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| 5. Round | 22/08/2021 | ŠKF Sereď | - | Slovan Bratislava | 0:1 | ||||
| 6. Round | 29/08/2021 | Slovan Bratislava | - | Zlaté Moravce | 4:1 | |
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| 7. Round | 12/09/2021 | FC DAC 1904 | - | Slovan Bratislava | 1:1 | ||||
| 8. Round | 19/09/2021 | Slovan Bratislava | - | MŠK Žilina | 2:2 | ||||
| 3. Round | 22/09/2021 | MFK Ružomberok | - | Slovan Bratislava | 1:0 | ||||
| 10. Round | 03/10/2021 | Slovan Bratislava | - | FK Pohronie | 5:1 | ||||
| 13. Round | 31/10/2021 | AS Trenčín | - | Slovan Bratislava | 2:3 | ||||
| 14. Round | 07/11/2021 | Slovan Bratislava | - | MFK Ružomberok | 1:0 | ||||
| 15. Round | 21/11/2021 | MFK Zemplín Michalovce | - | Slovan Bratislava | 1:2 | ||||
| 18. Round | 12/12/2021 | Slovan Bratislava | - | FC DAC 1904 | 0:0 | ||||
| 19. Round | 19/12/2021 | MŠK Žilina | - | Slovan Bratislava | 1:1 | ||||
| 22. Round | 26/02/2022 | Slovan Bratislava | - | Spartak Trnava | 0:0 |
Croatia
Slovakia