| 1. Round | 18/07/2021 | Salyut Belgorod | - | Zenit Penza | 3:1 | ||||
| 2. Round | 24/07/2021 | Zenit Penza | - | Sokol Saratov | 0:2 | ||||
| 3. Round | 01/08/2021 | Avangard Kursk | - | Zenit Penza | 4:0 |  |
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| 4. Round | 07/08/2021 | Zenit Penza | - | Fakel Voronezh 2 | 2:1 | ||||
| 6. Round | 21/08/2021 | Zenit Penza | - | FK Ryazan | 0:3 | ||||
| 10. Round | 14/09/2021 | Arsenal Tula 2 | - | Zenit Penza | 1:0 | ||||
| 14. Round | 04/10/2021 | Sokol Saratov | - | Zenit Penza | 3:0 | |
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| 20. Round | 03/11/2021 | Zenit Penza | - | Dinamo Vladivostok | 0:0 | |
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| 22. Round | 14/11/2021 | Zenit Penza | - | Arsenal Tula 2 | 1:5 |
Russia