| 1. Round | 18/07/2021 | FK Saransk | - | FK Khimki 2 | 1:0 |  |
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| 3. Round | 01/08/2021 | SKA-Khabarovsk 2 | - | FK Saransk | 0:3 | ||||
| 7. Round | 29/08/2021 | FK Kolomna | - | FK Saransk | 1:4 | ||||
| 9. Round | 10/09/2021 | FK Peresvet Podolsk | - | FK Saransk | 2:0 | ||||
| 13. Round | 30/09/2021 | FK Saransk | - | SKA-Khabarovsk 2 | 0:0 | ||||
| 14. Round | 04/10/2021 | FK Saransk | - | FK Znamya Noginsk | 1:0 | |
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| 16. Round | 14/10/2021 | Kvant Obninsk | - | FK Saransk | 1:4 | ||||
| 17. Round | 19/10/2021 | FK Saransk | - | FK Kolomna | 5:1 | ||||
| 18. Round | 25/10/2021 | Rodina Moskva | - | FK Saransk | 3:1 | |
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| 19. Round | 31/10/2021 | FK Saransk | - | FK Peresvet Podolsk | 3:2 | ||||
| 20. Round | 04/11/2021 | Metallurg Vidnoye | - | FK Saransk | 1:3 | ||||
| 22. Round | 14/11/2021 | FK Khimki 2 | - | FK Saransk | 1:2 |
Russia