| 1. Round | 25/07/2021 | Viktoria Plzeň | - | FK Mladá Boleslav | 2:1 | ||||
| 2. Round | 01/08/2021 | Bohemians Praha 1905 | - | Viktoria Plzeň | 1:2 | ||||
| 3. Round | 08/08/2021 | Viktoria Plzeň | - | 1. FC Slovácko | 2:1 | ||||
| 4. Round | 15/08/2021 | Slovan Liberec | - | Viktoria Plzeň | 0:1 |  |
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| 5. Round | 22/08/2021 | Viktoria Plzeň | - | MFK Karviná | 2:0 | ||||
| 15. Round | 20/11/2021 | Baník Ostrava | - | Viktoria Plzeň | 2:2 |
Czech Republic