| Group G | 14/09/2017 | FCSB | - | Viktoria Plzeň | 3:0 | ||||
| Group G | 28/09/2017 | Viktoria Plzeň | - | Hapoel Be'er Sheva | 3:1 | ||||
| Group G | 19/10/2017 | FC Lugano | - | Viktoria Plzeň | 3:2 | ||||
| Group G | 02/11/2017 | Viktoria Plzeň | - | FC Lugano | 4:1 | ||||
| Group G | 23/11/2017 | Viktoria Plzeň | - | FCSB | 2:0 | ||||
| Group G | 07/12/2017 | Hapoel Be'er Sheva | - | Viktoria Plzeň | 0:2 |  |
|||
| Round of 32 | 15/02/2018 | Partizan | - | Viktoria Plzeň | 1:1 | ||||
| Round of 32 | 22/02/2018 | Viktoria Plzeň | - | Partizan | 2:0 | ||||
| Round of 16 | 08/03/2018 | Sporting CP | - | Viktoria Plzeň | 2:0 | ||||
| Round of 16 | 15/03/2018 | Viktoria Plzeň | - | Sporting CP | 2:1 aet |
Czech Republic