| 1. Round | 08/01/2022 | CF Monterrey [U18] | - | Gallos Blancos [U18] | 3:2 | ||||
| 3. Round | 22/01/2022 | CF Monterrey [U18] | - | Cruz Azul [U18] | 1:0 | ||||
| 14. Round | 27/01/2022 | Pumas UNAM [U18] | - | CF Monterrey [U18] | 4:2 |  |
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| 4. Round | 06/02/2022 | Deportivo Toluca [U18] | - | CF Monterrey [U18] | 3:0 | ||||
| 5. Round | 12/02/2022 | CF Monterrey [U18] | - | FC Juárez [U18] | 2:1 | ||||
| 6. Round | 18/02/2022 | Puebla FC [U18] | - | CF Monterrey [U18] | 1:1 | ||||
| 7. Round | 26/02/2022 | CF Monterrey [U18] | - | Atlético San Luis [U18] | 2:4 | ||||
| 8. Round | 01/03/2022 | Club León [U18] | - | CF Monterrey [U18] | 2:0 | ||||
| 9. Round | 05/03/2022 | CF Monterrey [U18] | - | CF América [U18] | 3:5 | ||||
| 10. Round | 11/03/2022 | CF Monterrey [U18] | - | Mazatlán FC [U18] | 2:2 | ||||
| 11. Round | 19/03/2022 | UANL Tigres [U18] | - | CF Monterrey [U18] | 0:4 | ||||
| 12. Round | 02/04/2022 | Deportivo Guadalajara [U18] | - | CF Monterrey [U18] | 4:0 | ||||
| 17. Round | 30/04/2022 | CF Monterrey [U18] | - | Club Tijuana [U18] | 1:1 |
Mexico