 |
 |
|
|
| 01/04/2022 | 18:30 | Atlético San Luis | - | Mazatlán FC | 3:1 (0:0) | |
| 02/04/2022 | 18:15 | Club Necaxa | - | CF América | 2:2 (1:1) | |
| 18:15 | Cruz Azul | - | Atlas Guadalajara | 1:1 (1:1) | ||
| 18:15 | Deportivo Guadalajara | - | CF Monterrey | 4:0 (2:0) | ||
| 18:30 | FC Juárez | - | Pumas UNAM | 1:2 (1:1) | ||
| 03/04/2022 | 16:00 | Santos Laguna | - | CF Pachuca | 3:1 (1:0) | |
| 18:00 | UANL Tigres | - | Club Tijuana | 2:0 (0:0) | ||
| 18:30 | Deportivo Toluca | - | Puebla FC | 0:1 (0:1) | ||
| 18:30 | Club León | - | Gallos Blancos | 2:1 (1:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 12 | 8 | 3 | 1 | 26:13 | 13 | 37 |
| 2 |
|
Atlas Guadalajara | 12 | 7 | 5 | 0 | 19:8 | 11 | 37 |
| 3 |
|
Club León | 12 | 8 | 2 | 2 | 17:10 | 7 | 33 |
| 4 |
|
Deportivo Guadalajara | 12 | 7 | 3 | 2 | 25:12 | 13 | 32 |
| 5 |
|
Santos Laguna | 12 | 5 | 5 | 2 | 24:13 | 11 | 29 |
| 6 |
|
Club Tijuana | 12 | 5 | 3 | 4 | 20:21 | -1 | 29 |
| 7 |
|
CF Monterrey | 12 | 5 | 2 | 5 | 22:25 | -3 | 28 |
| 8 |
|
CF Pachuca | 12 | 6 | 0 | 6 | 21:19 | 2 | 25 |
| 9 |
|
Pumas UNAM | 12 | 5 | 3 | 4 | 14:13 | 1 | 25 |
| 10 |
|
Deportivo Toluca | 12 | 4 | 4 | 4 | 16:14 | 2 | 24 |
| 11 |
|
Cruz Azul | 12 | 4 | 2 | 6 | 13:16 | -3 | 23 |
| 12 |
|
UANL Tigres | 12 | 4 | 2 | 6 | 15:25 | -10 | 23 |
| 13 |
|
Atlético San Luis | 12 | 5 | 1 | 6 | 17:17 | 0 | 22 |
| 14 |
|
Mazatlán FC | 12 | 2 | 4 | 6 | 12:24 | -12 | 20 |
| 15 |
|
Club Necaxa | 12 | 3 | 2 | 7 | 15:21 | -6 | 18 |
| 16 |
|
Puebla FC | 12 | 1 | 5 | 6 | 7:16 | -9 | 17 |
| 17 |
|
Gallos Blancos | 12 | 3 | 0 | 9 | 8:17 | -9 | 16 |
| 18 |
|
FC Juárez | 12 | 1 | 4 | 7 | 14:21 | -7 | 14 |
| Playoffs |
