1. Round | 05/02/2022 | 12 de Octubre de Itauguá | - | Libertad | 1:6 | ||||
2. Round | 12/02/2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
3. Round | 20/02/2022 | Club Olimpia | - | Libertad | 2:2 | ||||
11. Round | 21/04/2022 | Libertad | - | Resistencia SC | 2:2 | ||||
12. Round | 23/04/2022 | Libertad | - | 12 de Octubre de Itauguá | 4:0 | ||||
13. Round | 30/04/2022 | General Caballero DJLM | - | Libertad | 0:1 | ||||
14. Round | 08/05/2022 | Libertad | - | Club Olimpia | 1:0 | ||||
15. Round | 11/05/2022 | Libertad | - | Tacuary | 3:0 | ||||
17. Round | 23/05/2022 | Libertad | - | Club Nacional | 1:0 | ||||
21. Round | 26/06/2022 | Libertad | - | Cerro Porteño | 1:0 |