| 1. Round | 06/11/2021 | Olympiakos Piraeus II | - | PAOK Saloniki II | 3:1 | ||||
| 10. Round | 29/12/2021 | Olympiakos Piraeus II | - | Anagennisi Karditsa | 0:1 | ||||
| 11. Round | 19/01/2022 | Pierikos Katerini | - | Olympiakos Piraeus II | 1:2 | ||||
| 15. Round | 22/01/2022 | Almopos Arideas | - | Olympiakos Piraeus II | 3:0 | ||||
| 16. Round | 30/01/2022 | Olympiakos Piraeus II | - | Niki Volou FC | 2:0 | ||||
| 12. Round | 02/02/2022 | Olympiakos Piraeus II | - | Xanthi FC | 1:1 | ||||
| 17. Round | 05/02/2022 | Olympiakos Volou | - | Olympiakos Piraeus II | 2:3 | ||||
| 18. Round | 13/02/2022 | PAOK Saloniki II | - | Olympiakos Piraeus II | 1:0 |  |
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| 19. Round | 16/02/2022 | Olympiakos Piraeus II | - | AO Trikala | 2:0 | ||||
| 21. Round | 26/02/2022 | Olympiakos Piraeus II | - | Apollon Lárissa | 0:1 | |
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| 29. Round | 06/04/2022 | Xanthi FC | - | Olympiakos Piraeus II | 2:1 | ||||
| 33. Round | 27/04/2022 | Niki Volou FC | - | Olympiakos Piraeus II | 0:1 | ||||
| 34. Round | 01/05/2022 | Olympiakos Piraeus II | - | Olympiakos Volou | 3:2 | |
Greece